Seema Irani

Identification of the Formycin A Biosynthetic Gene Cluster from <i>Streptomyces kaniharaensis</i> Illustrates the Interplay between Biological Pyrazolopyrimidine Formation and <i>de Novo</i> Purine Biosynthesis

Shao‐An Wang, Yeonjin Ko, Jia Zeng et al. · Journal of the American Chemical Society · 2019 · 59 citations · Full text

Bioorganic Chemistry, Engineering, Aldo-keto Reductase +16

Enzyme-mediated depletion of serum <scp>l</scp> -Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity

Weicheng Lu, Achinto Saha, Wupeng Yan et al. · Proceedings of the National Academy of Sciences · 2020 · 50 citations · Full text

Snapshots of C-S Cleavage in Egt2 Reveals Substrate Specificity and Reaction Mechanism

Seema Irani, Nathchar Naowarojna, Yang Tang et al. · Cell chemical biology · 2018 · 45 citations · Full text

Signal Transduction, Biochemistry, Natural Sciences +5

Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb

Joshua E. Mayfield, Seema Irani, Edwin E. Escobar et al. · eLife · 2019 · 40 citations · Full text

Mapping the Phosphorylation Pattern of <i>Drosophila melanogaster</i> RNA Polymerase II Carboxyl-Terminal Domain Using Ultraviolet Photodissociation Mass Spectrometry

Joshua E. Mayfield, Michelle Robinson, Victoria C. Cotham et al. · ACS Chemical Biology · 2016 · 30 citations · Full text

Molecular Regulation, Genetics, Molecular Biology +17