Seema Irani

Identification of the Formycin A Biosynthetic Gene Cluster from <i>Streptomyces kaniharaensis</i> Illustrates the Interplay between Biological Pyrazolopyrimidine Formation and <i>de Novo</i> Purine Biosynthesis

Shao‐An Wang, Yeonjin Ko, Jia Zeng et al. · Journal of the American Chemical Society · 2019 · 60 citations · Full text

Life Sciences, Microbiology, Molecular Biology +16

Enzyme-mediated depletion of serum <scp>l</scp> -Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity

Weicheng Lu, Achinto Saha, Wupeng Yan et al. · Proceedings of the National Academy of Sciences · 2020 · 54 citations · Full text

Life Sciences, Biochemistry, Cancer Biology +16

Snapshots of C-S Cleavage in Egt2 Reveals Substrate Specificity and Reaction Mechanism

Seema Irani, Nathchar Naowarojna, Yang Tang et al. · Cell chemical biology · 2018 · 47 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb

Joshua E. Mayfield, Seema Irani, Edwin E. Escobar et al. · eLife · 2019 · 41 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Crystal Structure of the Ergothioneine Sulfoxide Synthase from <i>Candidatus Chloracidobacterium thermophilum</i> and Structure-Guided Engineering To Modulate Its Substrate Selectivity

Nathchar Naowarojna, Seema Irani, Weiyao Hu et al. · ACS Catalysis · 2019 · 32 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15