Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: Solution and X-ray crystallographic studies

Murat Bozdağ, Marta Ferraroni, Elisa Nuti, +5

Bioorganic & Medicinal Chemistry

X-ray Crystallographic StudiesMedicinal ChemistryRing ApproachesBiochemistryNatural Sciences +7

New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2)

Armando Rossello, Elisa Nuti, Elisabetta Orlandini, +10

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryNatural SciencesMedicineGelatinase A +5

Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II

Takehiko Takayanagi, Steven J. Forrester, Tatsuo Kawai, +9

Hypertension

Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides

Tiziano Tuccinardi, Adriano Martinelli, Elisa Nuti, +5

Bioorganic & Medicinal Chemistry

Molecular Modelling StudyCombinatorial ChemistryMedicinal ChemistryPharmaceutical ScienceBioorganic Chemistry +11

<i>N</i>-<i>O</i>-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity

Elisa Nuti, Anna Rita Cantelmo, Cristina Gallo, +12

Journal of Medicinal Chemistry

PharmacotherapyChemical BiologyPharmaceutical ChemistryTumor BiologyNanomedicine +22

Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies

Elisa Nuti, Doretta Cuffaro, E. Bernardini, +12

Journal of Medicinal Chemistry

Structural Insights on Carbonic Anhydrase Inhibitory Action, Isoform Selectivity, and Potency of Sulfonamides and Coumarins Incorporating Arylsulfonylureido Groups

Murat Bozdağ, Marta Ferraroni, Fabrizio Carta, +8

Journal of Medicinal Chemistry

Combinatorial ChemistryPharmaceutical ScienceBioorganic ChemistryVivo Intraocular PressureOrganic Chemistry +20

<i>N-O-</i>Isopropyl Sulfonamido-Based Hydroxamates: Design, Synthesis and Biological Evaluation of Selective Matrix Metalloproteinase-13 Inhibitors as Potential Therapeutic Agents for Osteoarthritis

Elisa Nuti, Francesca Casalini, Stanislava I. Avramova, +13

Journal of Medicinal Chemistry

Tissue EngineeringPharmaceutical ScienceSclerostinEngineeringMmp-13 Synthetic Inhibitors +19

Crystallization of bi-functional ligand protein complexes

Claudia Antoni, Laura Vera, Laurent Devel, +7

Journal of Structural Biology

Coordination ComplexMolecular ComplexCrystallographyMolecular Biology

Inhibition of metalloproteinases derived from tumours: new insights in the treatment of human glioblastoma

P Gabelloni, Eleonora Da Pozzo, S Bendinelli, +7

Neuroscience

Neuro-oncologyMedicineMetalloproteinTumor TargetingNew Insights +9