Kang Zhu

HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation

Marcin J. Suskiewicz, Florian Zobel, T.E.H. Ogden et al. · Nature · 2020 · 257 citations · Full text

Transcriptional Regulation, Genome Instability, Dna Damage +8

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

M. Schuller, G.J. Correy, Stefan Gahbauer et al. · Science Advances · 2021 · 198 citations · Full text

Engineering, Nsp3 Macrodomain, Molecular Biology +16

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

Graeme Hewitt, Valérie Borel, Sandra Segura‐Bayona et al. · Molecular Cell · 2020 · 160 citations · Full text

DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates

Kang Zhu, Marcin J. Suskiewicz, Andrea Hloušek-Kasun et al. · Science Advances · 2022 · 101 citations · Full text

The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome

Ivo A. Hendriks, Sara C. Buch-Larsen, Evgeniia Prokhorova et al. · Nature Communications · 2021 · 96 citations · Full text