Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures

Robert Vander Velde, Nara Yoon, Viktoriya Marusyk, +15

Nature Communications

Clinical and Molecular Determinants of Clonal Evolution in Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Carmelo Gurnari, Simona Pagliuca, Pedro Henrique Prata, +20

Journal of Clinical Oncology

Machine learning integrates genomic signatures for subclassification beyond primary and secondary acute myeloid leukemia

Hassan Awada, Arda Durmaz, Carmelo Gurnari, +21

Blood

Measuring competitive exclusion in non–small cell lung cancer

Nathan Farrokhian, Jeff Maltas, Mina N. Dinh, +7

Science Advances

Identifying States of Collateral Sensitivity during the Evolution of Therapeutic Resistance in Ewing's Sarcoma

Jessica Scarborough, Erin McClure, Peter M. Anderson, +5

iScience

Development and characterization of patient-derived xenografts from non-small cell lung cancer brain metastases

Saakshi Kaushik, Arda Durmaz, Steve Goldstein, +9

Scientific Reports

Molecular patterns identify distinct subclasses of myeloid neoplasia

Tariq Kewan, Arda Durmaz, Waled Bahaj, +21

Nature Communications

Novel scheme for defining the clinical implications of TP53 mutations in myeloid neoplasia

Waled Bahaj, Tariq Kewan, Carmelo Gurnari, +16

Journal of Hematology & Oncology

Target-Independent Prediction of Drug Synergies Using Only Drug Lipophilicity

Kaan Yılancıoğlu, Zohar Weinstein, Cem Meydan, +7

Journal of Chemical Information and Modeling

Lead CompoundsDrug TargetHit IdentificationDrug ResistanceSystems Pharmacology +14

Validation of the Molecular International Prognostic Scoring System in patients with myelodysplastic syndromes

Tariq Kewan, Waled Bahaj, Arda Durmaz, +7

Blood