Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death

Xiaonan Wang, Xuejun Hu, Yang Yang, +2

Brain Research

Neurodegenerative DiseasesMolecular NeuroscienceMedicineNeuropharmacologyNeuronal Death +10

Cognitive dysfunction associates with white matter hyperintensities and subcortical atrophy on magnetic resonance imaging of the elderly diabetes mellitus Japanese elderly diabetes intervention trial (J‐EDIT)

Taichi Akisaki, Takashi Sakurai, Toshihiro Takata, +8

Diabetes/Metabolism Research and Reviews

Effects of deprivation of oxygen or glucose on the neural activity in the guinea pig hippocampal slice—intracellular recording study of pyramidal neurons

Toshihiro Takata, Yasuhiro Okada

Brain Research

Synaptic PlasticityNeurophysiologySynaptic TransmissionNeural CircuitsPhysiology +11

Effects of hypothermia on the neuronal activity, [Ca2+]i accumulation and ATP levels during oxygen and/or glucose deprivation in hippocampal slices of guinea pigs

Toshihiro Takata, Makoto Nabetani, Yasuhiro Okada

Neuroscience Letters

Animal PhysiologyEnergy HomeostasisHippocampal SlicesGuinea PigsNeurophysiology +10

Synaptic Adaptation to Repeated Hypoglycemia Depends on the Utilization of Monocarboxylates in Guinea Pig Hippocampal Slices

Takashi Sakurai, Bo Yang, Toshihiro Takata, +1

Diabetes

Synaptic TransmissionPostsynaptic Population SpikeNeurotransmitterRepeated HypoglycemiaNeurotransmission +16

Pyruvate Prevents the Inhibition of the Long-term Potentiation Induced by Amyloid-β through Protein Phosphatase 2A Inactivation

Xiaonan Wang, Toshihiro Takata, Xiaojuan Bai, +3

Journal of Alzheimer s Disease

Amyloid-β Protein PrecursorSynaptic TransmissionObserved Pyruvate ProtectionSynaptic SignalingSocial Sciences +24

Systemic pyruvate administration markedly reduces neuronal death and cognitive impairment in a rat model of Alzheimer's disease

Xiaonan Wang, Xuejun Hu, Yang Yang, +2

Experimental Neurology

Alzheimer's DiseaseNeurophysiologyDementiaPhysiologyVascular Dementia +11

Effect of lactate on the synaptic potential, energy metabolism, calcium homeostasis and extracellular glutamate concentration in the dentate gyrus of the hippocampus from guinea-pig

Toshihiro Takata, Takashi Sakurai, Bo Yang, +2

Neuroscience

Synaptic PlasticityNeurophysiologySynaptic TransmissionPhysiologyExtracellular Glutamate Concentration +8

Potassium attenuates zinc‐induced death of cultured cortical astrocytes

Christian T. Sheline, Toshihiro Takata, Howard S. Ying, +4

Glia

The release of glutamate and accumulation of intracellular calcium in the guinea pig hippocampal slices during glucose deprivation

Toshihiro Takata, Hirokazu Hirai, Takashi Shigernoto, +1

Neuroscience Letters

Synaptic PlasticityGlucose DeprivationNeurophysiologySynaptic TransmissionPhysiology +8