Frank G. Rücker

Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

Tobias Rausch, David Jones, Marc Zapatka et al. · Cell · 2012 · 868 citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations

Konstanze Döhner, Richard F. Schlenk, Marianne Habdank et al. · Blood · 2005 · 845 citations · Full text

Life Sciences, Genetics, Oncology +11

TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome

Frank G. Rücker, Richard F. Schlenk, Lars Bullinger et al. · Blood · 2011 · 678 citations · Full text

Life Sciences, Genetics, Oncology +17

A dominant-negative effect drives selection of <i>TP53</i> missense mutations in myeloid malignancies

Steffen Boettcher, Peter G. Miller, Rohan Sharma et al. · Science · 2019 · 434 citations · Full text

Life Sciences, Genetics, Oncology +14

Therapeutic targeting of preleukemia cells in a mouse model of <i>NPM1</i> mutant acute myeloid leukemia

Hannah J. Uckelmann, Stephanie M. Kim, Eric Wong et al. · Science · 2020 · 271 citations · Full text

Medicine, Cancer Biology, Oncology +15