Target identification using drug affinity responsive target stability (DARTS)

Brett Lomenick, Rui Hao, Nao Jonai, +14

Proceedings of the National Academy of Sciences

Drug TargetInteractomicsMolecular TargetDrug DiscoveryProteomics +12

Pyroptosis by caspase11/4‐gasdermin‐D pathway in alcoholic hepatitis in mice and patients

Elena Khanova, Raymond Wu, Wen Wang, +14

Hepatology

Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6

Keane K. Y. Lai, Soo-Mi Kweon, Feng Chi, +16

Gastroenterology

Signal TransductionHepatologySignaling PathwayLiver PhysiologyWnt Positive-signaling Loop +10

Circadian regulator BMAL1::CLOCK promotes cell proliferation in hepatocellular carcinoma by controlling apoptosis and cell cycle

Meng Qu, Guoxin Zhang, Han Qu, +8

Proceedings of the National Academy of Sciences

Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia

Raymond Wu, Tomoko Hayashi, Howard B. Cottam, +7

Proceedings of the National Academy of Sciences

Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice

Raul Lazaro, Raymond Wu, Sun‐Young Lee, +6

Hepatology

12-Lipoxygenase Products Reduce Insulin Secretion and β-Cell Viability in Human Islets

Kaixin Ma, Craig S. Nunemaker, Raymond Wu, +3

The Journal of Clinical Endocrinology & Metabolism

Alcohol directly stimulates epigenetic modifications in hepatic stellate cells

Agata Page, Pier Paoli, Stephen J. Hill, +8

Journal of Hepatology

ChromatinHepatologyMedicineLiver PhysiologyEpigenetic Modifications +8

Baicalein Targets GTPase‐Mediated Autophagy to Eliminate Liver Tumor–Initiating Stem Cell–Like Cells Resistant to mTORC1 Inhibition

Raymond Wu, Ramachandran Murali, Yasuaki Kabe, +7

Hepatology

The anti-inflammatory compound lisofylline prevents Type I diabetes in non-obese diabetic mice

Z Yang, Min Chen, Raymond Wu, +2

Diabetologia

InflammationMetabolic SyndromeObesityAnti-inflammatoryNon-obese Diabetic Mice +6