Kevin Docherty

Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes

Wendy M. Macfarlane, Timothy M. Frayling, Sian Ellard et al. · Journal of Clinical Investigation · 1999 · 255 citations · Full text

Medicine, Endocrinology, Genetics +17

Glucose Stimulates Translocation of the Homeodomain Transcription Factor PDX1 from the Cytoplasm to the Nucleus in Pancreatic β-Cells

Wendy M. Macfarlane, Caroline M. McKinnon, Zoë A. Felton-Edkins et al. · Journal of Biological Chemistry · 1999 · 218 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

The p38/Reactivating Kinase Mitogen-activated Protein Kinase Cascade Mediates the Activation of the Transcription Factor Insulin Upstream Factor 1 and Insulin Gene Transcription by High Glucose in Pancreatic β-Cells

Wendy M. Macfarlane, Stuart B. Smith, Roger F.L. James et al. · Journal of Biological Chemistry · 1997 · 176 citations · Full text

Life Sciences, Endocrinology, Molecular Biology +17

Positive and negative regulation of the human insulin gene by multiple trans-acting factors.

David S.W. Boam, Andrew R. Clark, Kevin Docherty · Journal of Biological Chemistry · 1990 · 158 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Glucose modulates the binding activity of the <i>β</i>-cell transcription factor IUF1 in a phosphorylation-dependent manner

Wendy M. Macfarlane, Martin L. Read, Moira G. Gilligan et al. · Biochemical Journal · 1994 · 134 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17