Total Synthesis of Vinblastine, Vincristine, Related Natural Products, and Key Structural Analogues

Hayato Ishikawa, David A. Colby, Shigeki Seto, +6

Journal of the American Chemical Society

Novel Seco Cyclopropa[<i>c</i>]pyrrolo[3,2-<i>e</i>]indole Bisalkylators Bearing a 3,3‘-Arylenebisacryloyl Group as a Linker

Yasumichi Fukuda, Shigeki Seto, Hirosuke Furuta, +3

Journal of Medicinal Chemistry

Compound 8Antitumor ActivityOrganic ChemistryChemistryHeterocycle Chemistry +14

Design, synthesis, and evaluation of novel 2-substituted-4-aryl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,5]oxazocin-5-ones as NK1 antagonists

Shigeki Seto, Asao Tanioka, Makoto Ikeda, +1

Bioorganic & Medicinal Chemistry

Medicinal ChemistryMedicineDrug DiscoveryNk1 AntagonistsHeterocycle Chemistry +4

Design and synthesis of novel 9-substituted-7-aryl-3,4,5,6-tetrahydro-2H-pyrido[4,3-b]- and [2,3-b]-1,5-oxazocin-6-ones as NK1 antagonists

Shigeki Seto, Asao Tanioka, Makoto Ikeda, +1

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryHeterocyclicNatural SciencesMedicineDiversity-oriented Synthesis +5

2-Substituted-4-aryl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,5]oxazocin-5-one as a structurally new NK1 antagonist

Shigeki Seto, Asao Tanioka, Makoto Ikeda, +1

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineMechanism Of ActionPharmacological AgentNew Nk1 Antagonist +3

Quinolone derivatives containing strained spirocycle as orally active glycogen synthase kinase 3β (GSK-3β) inhibitors for type 2 diabetics

Shigeki Seto, Kazuhiko Yumoto, Kyoko Okada, +7

Bioorganic & Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPharmaceutical ScienceBiochemistryMedicine +9

Synthesis and structure–activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3β

Oana M. Cociorva, Bei Li, Tyzoon Nomanbhoy, +16

Bioorganic & Medicinal Chemistry Letters

Structure–activity RelationshipMolecular PharmacologyMedicinal ChemistryBiochemistry4-Quinolone-3-carboxylic Acid +10

Novel pyrazolo[1,5-a]pyridines as orally active EP1 receptor antagonists: Synthesis, structure-activity relationship studies, and biological evaluation

Kentaro Umei, Yosuke Nishigaya, Atsushi Kondo, +4

Bioorganic & Medicinal Chemistry

The novel cyclopropapyrroloindole(CPI) bisalkylators bearing 3,3′-(1,4-phenylene)diacryloyl group as a linker

Yasumichi Fukuda, Shigeki Seto, Hirosuke Furuta, +3

Bioorganic & Medicinal Chemistry Letters

EngineeringHeterocyclicOrganic ChemistryChemistryDiacryloyl Group +2

Design, Synthesis, and Structure−Activity Relationship Studies of Novel 2,4,6-Trisubstituted-5-pyrimidinecarboxylic Acids as Peroxisome Proliferator-Activated Receptor γ (PPARγ) Partial Agonists with Comparable Antidiabetic Efficacy to Rosiglitazone

Shigeki Seto, Kyoko Okada, Koichi Kiyota, +6

Journal of Medicinal Chemistry

Pharmaceutical ScienceBioorganic ChemistryPharmacotherapyCompound 9Chemical Biology +16