James Zapf

A transient interaction between two phosphorelay proteins trapped in a crystal lattice reveals the mechanism of molecular recognition and phosphotransfer in signal transduction

James Zapf, U. Sen, M. D. Madhusudan et al. · Structure · 2000 · 168 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Allosteric silencing of activating function 1 in the 4-hydroxytamoxifen estrogen receptor complex is induced by substituting glycine for aspartate at amino acid 351.

Jennifer MacGregor Schafer, H Liu, David J. Bentrem et al. · PubMed · 2000 · 110 citations

Life Sciences, Biochemistry, Endocrinology +16

Molecular Mechanism of Action at Estrogen Receptor α of a New Clinically Relevant Antiestrogen (GW7604) Related to Tamoxifen**This work was supported by NIH CA-56143 (to V.C.J.); Fundacao Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, (CAPES) Scholarship, Brazil (to R.D.); the U.S. Army Medical Research and Material Command Breast Cancer Research Program, DAMD17–96-16169 (to H.L.); the generosity of the Lynn Sage Breast Cancer Research Foundation of Northwestern Memorial Hospital; and the Avon Products Foundation.

David J. Bentrem, R. C. Dardes, Hong Liu et al. · Endocrinology · 2001 · 94 citations

Medicine, Endocrinology, Pharmacology +11

Structure-Function Relationships of the Raloxifene-Estrogen Receptor-α Complex for Regulating Transforming Growth Factor-α Expression in Breast Cancer Cells

Hong Liu, Woo Chan Park, David J. Bentrem et al. · Journal of Biological Chemistry · 2002 · 80 citations · Full text

Medicine, Oncology, Pharmacology +16

Silencing and reactivation of the selective estrogen receptor modulator-estrogen receptor alpha complex.

H. Liu, E S Lee, A Deb Los Reyes et al. · PubMed · 2001 · 75 citations

Life Sciences, Endocrinology, Pharmacology +17