Inhibition of USP10 induces degradation of oncogenic FLT3

Ellen Weisberg, Nathan J. Schauer, Jing Yang, +25

Nature Chemical Biology

Oncogenic AgentNatural SciencesMolecular BiologyExperimental ToxicologyGene Expression +1

Comparison of effects of midostaurin, crenolanib, quizartinib, gilteritinib, sorafenib and BLU‐285 on oncogenic mutants of KIT, CBL and FLT3 in haematological malignancies

Ellen Weisberg, Chengcheng Meng, Abigail E. Case, +13

British Journal of Haematology

Mast Cell DisorderImmunologyPathologyStructural SimilarityImmunotherapy +20

BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma

Ellen Weisberg, Basudev Chowdhury, Chengcheng Meng, +30

Blood Cancer Journal

The cancer-associated CTCFL/BORIS protein targets multiple classes of genomic repeats, with a distinct binding and functional preference for humanoid-specific SVA transposable elements

Elena M. Pugacheva, Evgeny Teplyakov, Qiongfang Wu, +10

Epigenetics & Chromatin

HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation

Yufeng Xiao, Seth Hale, Nikee Awasthee, +10

Cell chemical biology

Histone ModificationsEpigenetic ChangeGeneticsMolecular BiologyMolecular Genetics +14

Inhibition of the deubiquitinase USP10 induces degradation of SYK

Jing Yang, Chengcheng Meng, Ellen Weisberg, +11

British Journal of Cancer

Small molecule inhibition of deubiquitinating enzyme JOSD1 as a novel targeted therapy for leukemias with mutant JAK2

Jing Yang, Ellen Weisberg, Xiaoxi Liu, +15

Leukemia

Hematological MalignancyNovel TherapyNatural SciencesReceptor Tyrosine KinaseMalignant Blood Disorder +10

Characterization of midostaurin as a dual inhibitor of FLT3 and SYK and potentiation of FLT3 inhibition against FLT3-ITD-driven leukemia harboring activated SYK kinase

Ellen Weisberg, Alexandre Puissant, Richard M. Stone, +13

Oncotarget

Effects of the multi‐kinase inhibitor midostaurin in combination with chemotherapy in models of acute myeloid leukaemia

Ellen Weisberg, Chengcheng Meng, Abigail E. Case, +11

Journal of Cellular and Molecular Medicine

DAXX drives de novo lipogenesis and contributes to tumorigenesis

Iqbal Mahmud, Guimei Tian, Jia Wang, +21

Nature Communications