Sammy H. S. Chan

Interactions between nascent proteins and the ribosome surface inhibit co-translational folding

Anaïs M. E. Cassaignau, Tomasz Włodarski, Sammy H. S. Chan et al. · Nature Chemistry · 2021 · 55 citations · Full text

Most Proteins, Protein Function, Protein Assembly +15

Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein

Elena Plessa, Lien Chu, Sammy H. S. Chan et al. · Nature Communications · 2021 · 55 citations · Full text

Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis

Christopher A. Waudby, Tomasz Włodarski, Maria‐Evangelia Karyadi et al. · Proceedings of the National Academy of Sciences · 2018 · 53 citations · Full text

Biophysical Modeling, Protein Assembly, Molecular Biology +24

Modulating co-translational protein folding by rational design and ribosome engineering

Minkoo Ahn, Tomasz Włodarski, Alkistis Mitropoulou et al. · Nature Communications · 2022 · 50 citations · Full text

The ribosome stabilizes partially folded intermediates of a nascent multi-domain protein

Sammy H. S. Chan, Tomasz Włodarski, Julian O. Streit et al. · Nature Chemistry · 2022 · 50 citations · Full text