Jian Liu

Dynamics-Based Discovery of Novel, Potent Benzoic Acid Derivatives as Orally Bioavailable Selective Estrogen Receptor Degraders for ERα+ Breast Cancer

Xiaomeng Zhang, Yazhou Wang, Xue Li et al. · Journal of Medicinal Chemistry · 2021 · 39 citations · Full text

Discovery of a Potent and Selective FLT3 Inhibitor (<i>Z</i>)-<i>N</i>-(5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-4-methyl-1<i>H</i>-pyrrol-3-yl)-3-(pyrrolidin-1-yl)propanamide with Improved Drug-like Properties and Superior Efficacy in FLT3-ITD-Positive Acute Myeloid Leukemia

Junwei Wang, Xiang Pan, Yi Song et al. · Journal of Medicinal Chemistry · 2021 · 27 citations · Full text

Design, synthesis and biological evaluation of indolin-2-one-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase3 (FLT3)

Fei Ma, Peng Liu, Min Lei et al. · European Journal of Medicinal Chemistry · 2016 · 25 citations · Full text

Fms-like Tyrosine Kinase3, Medicinal Chemistry, Biochemistry +9

Discovery of 1,6-Naphthyridin-2(1<i>H</i>)-one Derivatives as Novel, Potent, and Selective FGFR4 Inhibitors for the Treatment of Hepatocellular Carcinoma

Xiaomeng Zhang, Yazhou Wang, Jianfeng Ji et al. · Journal of Medicinal Chemistry · 2022 · 25 citations · Full text

Diastereoselective construction of 3-aryl-substituted indolines <i>via</i> annulation of <i>in situ</i> generated <i>p</i>-quinone methides

Junwei Wang, Xiang Pan, Lei Zhao et al. · Organic & Biomolecular Chemistry · 2019 · 21 citations

Diastereoselective Construction, Chemical Engineering, P-quinone Methides +12