Raine E. S. Thomson

Engineering highly functional thermostable proteins using ancestral sequence reconstruction

Yosephin Gumulya, Jong‐Min Baek, Shun Jie Wun et al. · Nature Catalysis · 2018 · 187 citations

Structural Bioinformatics, Protein Folding, Natural Sciences +7

Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP)

Gabriel Foley, Ariane Mora, Connie M. Ross et al. · PLoS Computational Biology · 2022 · 59 citations · Full text

Substitution Variants, Genetics, Molecular Biology +19

Confirmation of a suspected 16q deletion in a dysmorphic child by flow karyotype analysis.

Alexander Cooke, John Tolmie, W Darlington et al. · Journal of Medical Genetics · 1987 · 34 citations · Full text

Genetic Testing, Flow Karyotype Analysis, Cytogenetics +18

Ancestral Sequence Reconstruction of a Cytochrome P450 Family Involved in Chemical Defense Reveals the Functional Evolution of a Promiscuous, Xenobiotic-Metabolizing Enzyme in Vertebrates

Kurt L. Harris, Raine E. S. Thomson, Yosephine Gumulya et al. · Molecular Biology and Evolution · 2022 · 27 citations · Full text

Engineering Thermostable CYP2D Enzymes for Biocatalysis Using Combinatorial Libraries of Ancestors for Directed Evolution (CLADE)

Yosephine Gumulya, Weiliang Huang, Stephlina A. D'Cunha et al. · ChemCatChem · 2018 · 24 citations

Engineering, Molecular Biology, Metabolic Networks +16