Perioperative COX-2 and β-Adrenergic Blockade Improves Metastatic Biomarkers in Breast Cancer Patients in a Phase-II Randomized Trial

Lee Shaashua, Maytal Shabat-Simon, Rita Haldar, +11

Clinical Cancer Research

Reducing liver metastases of colon cancer in the context of extensive and minor surgeries through β-adrenoceptors blockade and COX2 inhibition

Liat Sorski, Rivka Melamed, Pini Matzner, +4

Brain Behavior and Immunity

Surgical OncologyOncologyHepatologyCox2 InhibitionGastrointestinal Oncology +10

Perioperative inhibition of β-adrenergic and COX2 signaling in a clinical trial in breast cancer patients improves tumor Ki-67 expression, serum cytokine levels, and PBMCs transcriptome

Rita Haldar, Lee Shaashua, Hagar Lavon, +9

Brain Behavior and Immunity

Breast OncologyBreast Cancer PatientsMedicinePharmacologyBreast Cancer +6

In vivo suppression of NK cell cytotoxicity by stress and surgery: Glucocorticoids have a minor role compared to catecholamines and prostaglandins

Ella Rosenne, Liat Sorski, Lee Shaashua, +4

Brain Behavior and Immunity

InflammationImmunotherapyVivo SuppressionMedicineImmunology +9

BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling

Lee Shaashua, Aviad Ben‐Shmuel, Meirav Pevsner‐Fischer, +26

Nature Communications

Infant sleep and early parental sleep-related cognitions predict sleep in pre-school children

Liat Tikotzky, Lee Shaashua

Sleep Medicine

Sleep MedicineChild PsychologySleepSleep DisordersCognitive Science +12

Perioperative treatment with the new synthetic <scp>TLR</scp>‐4 agonist <scp>GLA‐SE</scp> reduces cancer metastasis without adverse effects

Pini Matzner, Liat Sorski, Lee Shaashua, +8

International Journal of Cancer

Surgical OncologyCancer ManagementImmunologyImmune RegulationImmunoediting +21

Prophylactic TLR9 stimulation reduces brain metastasis through microglia activation

Amit Benbenishty, Meital Gadrich, Azzurra Cottarelli, +10

PLoS Biology

InflammationCancer ImmunosurveillanceGliomaBrain MetastasesMedicine +13

Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer

Linda Bojmar, Constantinos P. Zambirinis, Jonathan M. Hernandez, +71

Nature Medicine

Pre-metastatic LiverSurgical OncologyPancreatic CancerHepatologyMedicine +7

Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2

Serena Lucotti, Yusuke Ogitani, Candia M. Kenific, +41

Cell

Extracellular VesiclesTumor BiologyIntegrin Beta 2Endocytic PathwayCell-matrix Interaction +8