CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities

Kyuho Han, Sarah E. Pierce, Amy Li, +22

Nature

Crispr ScreensGene EditingGenome EditingMedicineCell Biology +2

The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery

Michinori Toriyama, Chanjae Lee, S. Paige Taylor, +29

Nature Genetics

Signal TransductionIntraflagellar Transport MachineryIntracellular TransportOrganelle DynamicCell Trafficking +11

Interpretation of cancer mutations using a multiscale map of protein systems

Fan Zheng, Marcus R. Kelly, Dana J. Ramms, +29

Science

EngineeringGeneticsMolecular BiologyPathologyCancer Mutations +24

A multi-scale map of cell structure fusing protein images and interactions

Yue Qin, Edward L. Huttlin, Casper F. Winsnes, +25

Nature

Cell StructureMulti-scale MapEngineeringInteractomicsMedicine +10

Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex

Siyuan Ding, Nancie A. Mooney, Bin Li, +7

PLoS Pathogens

Viral ImmunityImmunologyViral PathogenesisMolecular BiologyInnate Immunity +17

Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis

Bin Li, Siyuan Ding, Ningguo Feng, +11

Proceedings of the National Academy of Sciences

Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities

Marcus R. Kelly, Kaja Kostyrko, Kyuho Han, +9

Cancer Discovery

A deep learning model of tumor cell architecture elucidates response and resistance to CDK4/6 inhibitors

Sungjoon Park, Erica Silva, Akshat Singhal, +11

Nature Cancer

UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma

Kaja Kostyrko, Marta Román, Alex G. Lee, +9

Nature Communications

A multi-scale map of protein assemblies in the DNA damage response

Anton Kratz, Minkyu Kim, Marcus R. Kelly, +16

Cell Systems

Dna DamageProtein AssemblyStructural BioinformaticsGeneticsMolecular Biology +22