Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding

Eliana Marinari, Aida Mehonic, Scott Curran, +3

Nature

Cell ProliferationCell GrowthMedicineCell BiologyCellular Physiology +1

Cdc42, Par6, and aPKC Regulate Arp2/3-Mediated Endocytosis to Control Local Adherens Junction Stability

Eliana Marinari, Jemima J. Burden, Buzz Baum

Current Biology

Signal TransductionMolecular PhysiologySignaling PathwayEndocytic PathwayIntracellular Trafficking +6

Responsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models

Vassilis Genoud, Eliana Marinari, Sergey I. Nikolaev, +5

OncoImmunology

Repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab show no efficacy in glioblastoma: a phase 1 trial

Stephen Bagley, Zev A. Binder, Lamia Lamrani, +32

Nature Cancer

GliomaImmunotherapyMedicineImmunologyPembrolizumab Show +9

Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients

Denis Migliorini, Valérie Dutoit, Mathilde Allard, +18

Neuro-Oncology

CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

Sara Costa-Cabral, Rachel Brough, Asha Konde, +8

PLoS ONE

Kras MutationsKras Mutant TumoursOncogenic AgentMedicineKras/cdk1 Interaction +11

Inflammation and lymphocyte infiltration are associated with shorter survival in patients with high-grade glioma

Eliana Marinari, Mathilde Allard, R Gustave, +6

OncoImmunology

ImmunologyPathologyImmunophenotypingHigh-grade GliomasGlioma +18

Decitabine Treatment of Glioma-Initiating Cells Enhances Immune Recognition and Killing

Cristina Riccadonna, Céline Yacoub Maroun, Romain Vuillefroy de Silly, +11

PLoS ONE

ImmunologyCell DeathHigh-grade GliomasImmunotherapyCancer Biology +14

Antigenic expression and spontaneous immune responses support the use of a selected peptide set from the IMA950 glioblastoma vaccine for immunotherapy of grade II and III glioma

Valérie Dutoit, Denis Migliorini, Giulia Ranzanici, +10

OncoImmunology

ImmunologyImmunoeditingImmunotherapeuticsHigh-grade GliomasImmunotherapy +18

Exploratory Study of the Effect of IMA950/Poly-ICLC Vaccination on Response to Bevacizumab in Relapsing High-Grade Glioma Patients

Emma Boydell, Eliana Marinari, Denis Migliorini, +3

Cancers