Metformin decelerates aging clock in male monkeys

Yuan‐Han Yang, Xiaoyong Lu, Ning Liu, +41

Cell

LongevityPhysiologyMale MonkeysNeuroscienceBiogerontology +4

LncRNA-p23154 promotes the invasion-metastasis potential of oral squamous cell carcinoma by regulating Glut1-mediated glycolysis

Yun Wang, Xiaojie Zhang, Zhi Wang, +10

Cancer Letters

Glut1-mediated GlycolysisInvasion-metastasis PotentialOral Potentially Malignant DisordersMedicineOral Biology +9

Obesity and genes related to lipid metabolism predict poor survival in oral squamous cell carcinoma

Qinchao Hu, Jianmin Peng, Xijuan Chen, +4

Oral Oncology

ObesityLipid SynthesisMedicinePathologyOncology +5

Modulation of IL-1β reprogrammes the tumor microenvironment to interrupt oral carcinogenesis

Tong Wu, Yun Hong, Lihua Jia, +5

Scientific Reports

Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma

Qinchao Hu, Jianmin Peng, Laibo Jiang, +8

Cell Death and Disease

Modulating autophagy to boost the antitumor efficacy of TROP2-directed antibody-drug conjugate in pancreatic cancer

Caili Xu, Xiting Huang, Qinchao Hu, +7

Biomedicine & Pharmacotherapy

Diet-induced obesity accelerates oral carcinogenesis by recruitment and functional enhancement of myeloid-derived suppressor cells

Jianmin Peng, Qinchao Hu, Xijuan Chen, +10

Cell Death and Disease

Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation

Yaobin Jing, Xiaoyu Jiang, Qianzhao Ji, +16

Cell stem cell

Genome InstabilityGeneticsCell DeathGenome-wide Crispr ActivationGene Editing +5

ASCT2 overexpression is associated with poor survival of OSCC patients and ASCT2 knockdown inhibited growth of glutamine‐addicted OSCC cells

Yijun Luo, Wei Li, Zihang Ling, +4

Cancer Medicine

Tumor-colonized Streptococcus mutans metabolically reprograms tumor microenvironment and promotes oral squamous cell carcinoma

Jiaying Zhou, Zixuan Hu, Lei Wang, +17

Microbiome

Tumor BiologyOncogenic AgentMedicineBiological MicroenvironmentsPathology +8