Laura Sandra Lello

A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research

Suzannah J. Rihn, Andres Merits, Siddharth Bakshi et al. · PLoS Biology · 2021 · 237 citations · Full text

Engineering, Genetics, Immunology +19

Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold

Yaw Bia Tan, Laura Sandra Lello, Xin Liu et al. · Nucleic Acids Research · 2021 · 43 citations · Full text

Viral Rna Replication, Virus Structure, Viral Replication +14

nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity

Laura Sandra Lello, Koen Bartholomeeusen, Sainan Wang et al. · Journal of Virology · 2021 · 41 citations · Full text

Synergistic Interferon-Alpha-Based Combinations for Treatment of SARS-CoV-2 and Other Viral Infections

Aleksandr Ianevski, Rouan Yao, Eva Žusinaite et al. · Viruses · 2021 · 32 citations · Full text

Cross-utilisation of template RNAs by alphavirus replicases

Laura Sandra Lello, Age Utt, Koen Bartholomeeusen et al. · PLoS Pathogens · 2020 · 30 citations · Full text

Virus Structure, Viral Replication, Viral Rna Genome +14