Lukas J.A.C. Hawinkels

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

Seth B. Coffelt, Kelly Kersten, Chris W. Doornebal et al. · Nature · 2015 · 1.7K citations

Breast Cancer Metastasis, Cancer Immunosurveillance, Lymphocyte Development +8

Tumor-draining lymph nodes are pivotal in PD-1/PD-L1 checkpoint therapy

Marieke F. Fransen, Mark J.A. Schoonderwoerd, Philipp Knopf et al. · JCI Insight · 2018 · 370 citations · Full text

Lymphoid Neoplasia, Tumor Immunology, Cancer Immunosurveillance +14

Matrix Metalloproteinase-14 (MT1-MMP)–Mediated Endoglin Shedding Inhibits Tumor Angiogenesis

Lukas J.A.C. Hawinkels, Patricia Kuiper, Eliza Wiercinska et al. · Cancer Research · 2010 · 265 citations

Membrane-localized Mmp-14, Angiogenesis, Endothelial Dysfunction +15

Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts

Lukas J.A.C. Hawinkels, Madelon Paauwe, Hein W. Verspaget et al. · Oncogene · 2012 · 249 citations

Cancer Research, Oncology, Medicine +11

VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis

Lukas J.A.C. Hawinkels, Kim Zuidwijk, Hein W. Verspaget et al. · European Journal of Cancer · 2008 · 206 citations

Oncology, Angiogenesis, Vegf Release +11