David Machalz

Next generation 3D pharmacophore modeling

David Schaller, Dora Šribar, Theresa Noonan et al. · Wiley Interdisciplinary Reviews Computational Molecular Science · 2020 · 250 citations · Full text

Engineering, Machine Learning, Computational Chemistry +23

Efficient substrate screening and inhibitor testing of human CYP4Z1 using permeabilized recombinant fission yeast

Yan Qi, David Machalz, Andy Zöllner et al. · Biochemical Pharmacology · 2017 · 48 citations

Molecular Biological Method, Efficient Substrate Screening, Natural Sciences +10

Functional characterization and mechanistic modeling of the human cytochrome P450 enzyme CYP4A22

Pradeepraj Durairaj, Linbing Fan, David Machalz et al. · FEBS Letters · 2019 · 29 citations · Full text

Orphan Cyp, Molecular Biology, Human Cytochrome P450 +16

Importance of asparagine-381 and arginine-487 for substrate recognition in CYP4Z1

Wei Du, David Machalz, Yan Qi et al. · Biochemical Pharmacology · 2020 · 22 citations

Molecular Characterization, Biochemistry, Natural Sciences +8

Discovery of a novel potent cytochrome P450 CYP4Z1 inhibitor

David Machalz, Hongjie Li, Wei Du et al. · European Journal of Medicinal Chemistry · 2021 · 22 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +6