THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

S P H Alexander, Arthur Christopoulos, Anthony P. Davenport, +151

British Journal of Pharmacology

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

S P H Alexander, Arthur Christopoulos, Anthony P. Davenport, +162

British Journal of Pharmacology

Drug TargetPeptide ScienceSystem PharmacologySystems PharmacologyMolecular Pharmacology +14

The Receptor-Bound “Empty Pocket” State of the Heterotrimeric G-Protein α-Subunit Is Conformationally Dynamic

N.G. Abdulaev, Tony Ngo, Eva Ramon, +3

Biochemistry

Protein AssemblyMolecular BiologyProtein FoldingHeterotrimeric G-protein ActivationEmpty Pocket +14

Structural basis for GPCR-independent activation of heterotrimeric Gi proteins

Nicholas A. Kalogriopoulos, Steven D. Rees, Tony Ngo, +7

Proceedings of the National Academy of Sciences

RETRACTED ARTICLE: Orphan receptor ligand discovery by pickpocketing pharmacological neighbors

Tony Ngo, Andrey V. Ilatovskiy, Alastair G. Stewart, +7

Nature Chemical Biology

Molecular PharmacologyDrug RepositioningDrug TargetFunctional SelectivityMedicine +7

Functional anatomy of the full-length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis

Bryan S. Stephens, Tony Ngo, Irina Kufareva, +1

Science Signaling

Drug TargetFull-length Cxcr4-cxcl12 ComplexMolecular BiologyReceptor N TerminusSignaling Pathway +17

Rapid Knockout and Reporter Mouse Line Generation and Breeding Colony Establishment Using EUCOMM Conditional-Ready Embryonic Stem Cells: A Case Study

James L. J. Coleman, Karen Brennan, Tony Ngo, +3

Frontiers in Endocrinology

GeneticsRapid KnockoutStem Cell BiologyEmbryologyStem Cells +16

Functionally Discrete Mimics of Light-activated Rhodopsin Identified through Expression of Soluble Cytoplasmic Domains

N.G. Abdulaev, Tony Ngo, Ruiwu Chen, +2

Journal of Biological Chemistry

Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity

Tony Ngo, Bryan S. Stephens, Martin Gustavsson, +4

PLoS Biology

Conformational Changes Associated with Receptor-stimulated Guanine Nucleotide Exchange in a Heterotrimeric G-protein α-Subunit

Kevin D. Ridge, N.G. Abdulaev, Cheng Zhang, +3

Journal of Biological Chemistry

Molecular BiologyConformational ChangesChemical BiologyMolecular PharmacologyNmr Methods +15