Pratiq A. Patel

Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

Kellie A. Jurado, Hao Wang, Alison Slaughter et al. · Proceedings of the National Academy of Sciences · 2013 · 205 citations · Full text

Medicine, Molecular Biology, Pharmacology +17

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

Hao Wang, Kellie A. Jurado, Xiaolin Wu et al. · Nucleic Acids Research · 2012 · 101 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +7

The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

Lei Feng, Amit Sharma, Alison Slaughter et al. · Journal of Biological Chemistry · 2013 · 94 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +13

The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase

Alison Slaughter, Kellie A. Jurado, Nanjie Deng et al. · Retrovirology · 2014 · 41 citations · Full text

Life Sciences, Biology, Molecular Biology +17

Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones

John L. Woodard, Andrew C. Huntsman, Pratiq A. Patel et al. · Bioorganic & Medicinal Chemistry · 2018 · 26 citations

Pharmacy, Chemistry, Medicinal Chemistry +12