W. John Langlois

Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation.

Toshiyasu Sasaoka, Boris Draznin, J. Wayne Leitner et al. · Journal of Biological Chemistry · 1994 · 200 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Negative Feedback Regulation and Desensitization of Insulin- and Epidermal Growth Factor-stimulated p21ras Activation

W. John Langlois, Toshiyasu Sasaoka, Alan R. Saltiel et al. · Journal of Biological Chemistry · 1995 · 186 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Molecular Cloning of Rat SH2-Containing Inositol Phosphatase 2 (SHIP2) and Its Role in the Regulation of Insulin Signaling

Hajime Ishihara, Toshiyasu Sasaoka, Hiroyuki Hori et al. · Biochemical and Biophysical Research Communications · 1999 · 133 citations

Life Sciences, Biochemistry, Molecular Biology +14

The signaling pathway coupling epidermal growth factor receptors to activation of p21ras.

Toshiyasu Sasaoka, W. John Langlois, J. Wayne Leitner et al. · Journal of Biological Chemistry · 1994 · 121 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Functional characterization of hybrid receptors composed of a truncated insulin receptor and wild type insulin-like growth factor 1 or insulin receptors.

W. John Langlois, Toshiyasu Sasaoka, Christopher Yip et al. · Endocrinology · 1995 · 36 citations

Life Sciences, Biochemistry, Molecular Biology +14