IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice

Tilo Biedermann, Stephan Zimmermann, Hayo Himmelrich, +11

Nature Immunology

InflammationAutoimmune DiseaseAllergyImmune RegulationImmunology +6

The IL-4 rapidly produced in BALB/c mice after infection with Leishmania major down-regulates IL-12 receptor beta 2-chain expression on CD4+ T cells resulting in a state of unresponsiveness to IL-12.

Hayo Himmelrich, Carlos Parra-López, Fabienne Tacchini‐Cottier, +2

PubMed

InflammationAutoimmune DiseaseAllergyMedicineImmune Regulation +13

In BALB/c Mice, IL-4 Production During the Initial Phase of Infection with <i>Leishmania major</i> Is Necessary and Sufficient to Instruct Th2 Cell Development Resulting in Progressive Disease

Hayo Himmelrich, Pascal Launois, Ivan Maillard, +5

The Journal of Immunology

The IL-4 Rapidly Produced in BALB/c Mice After Infection with <i>Leishmania major</i> Down-Regulates IL-12 Receptor β2-Chain Expression on CD4+ T Cells Resulting in a State of Unresponsiveness to IL-12

Hayo Himmelrich, Carlos Parra-López, Fabienne Tacchini‐Cottier, +2

The Journal of Immunology

Adaptive Immune SystemImmunodeficienciesImmune RegulationImmunologyImmunodominance +20

<i>Leishmania major</i>-Specific B Cells Are Necessary for Th2 Cell Development and Susceptibility to <i>L. major</i> LV39 in BALB/c Mice

Catherine Ronet, Heike Voigt, Hayo Himmelrich, +7

The Journal of Immunology

Immune responses induced by recombinant BCG strains according to level of production of a foreign antigen: MalE

Hayo Himmelrich, Richard Lo‐Man, Nathalie Winter, +10

Vaccine

Autoimmune DiseasePathogenesisImmunologyInnate Immune SystemImmunodominance +8

Rapid IL-4 Production by <i>Leishmania</i> Homolog of Mammalian RACK1-Reactive CD4+ T Cells in Resistant Mice Treated Once with Anti-IL-12 or -IFN-γ Antibodies at the Onset of Infection with <i>Leishmania major</i> Instructs Th2 Cell Development, Resulting in Nonhealing Lesions

Pascal Launois, Alain Gumy, Hayo Himmelrich, +3

The Journal of Immunology

Functional plasticity of the LACK-reactive Vβ4-Vα8 CD4+ T cells normally producing the early IL-4 instructing Th2 cell development and susceptibility toLeishmania major in BALB / c mice

Ivan Maillard, Pascal Launois, Hayo Himmelrich, +4

European Journal of Immunology

Lymphocyte DevelopmentAdaptive Immune SystemImmune RegulationImmunologyImmunodominance +20

Different epitopes of the LACK protein are recognized by Vβ4 Vα8 CD4+ T cells in H-2b and H-2d mice susceptible to Leishmania major

Pascal Launois, Sabine Pingel, Hayo Himmelrich, +2

Microbes and Infection

Lack ProteinMedicinePathogenesisImmunologyPathology +8

IL‐12p40‐independent induction of protective immunity upon multiple <i>Plasmodium berghei</i> irradiated sporozoite immunizations

Jorge Romero, Grace Ibrahim, John Renggli, +3

Parasite Immunology

Sporozoite ImmunizationsAdaptive Immune SystemP. BergheiMedicineMalaria +13