Darren J. Fitzpatrick

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

James O. Early, Deepthi Menon, Cathy Wyse et al. · Proceedings of the National Academy of Sciences · 2018 · 340 citations · Full text

PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation

Evan Healy, Marlena Mucha, Eleanor Glancy et al. · Molecular Cell · 2019 · 205 citations · Full text

Natural Sciences, Proton Transfer, Molecular Biology +3

The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells

Gundula Streubel, Ariane Watson, Sri Ganesh Jammula et al. · Molecular Cell · 2018 · 176 citations · Full text

Chromatin, Developmental Biology, H3k36me2 Methyltransferase Nsd1 +12

A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities

Eric Conway, Emilia Jerman, Evan Healy et al. · Molecular Cell · 2018 · 158 citations · Full text

Chromatin, Vertebrate-specific Polycombs Encoded, Genetics +8

Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells

Gerard L. Brien, Raul Bardini Bressan, Craig Monger et al. · Nature Genetics · 2021 · 70 citations · Full text

Chromatin, Enhancer Function Underlies, H3.3-k27m Oncogenic Activity +12