Andy J. Liedtke

Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer

Andy J. Liedtke, Adegoke O. Adeniji, Mo Chen et al. · Journal of Medicinal Chemistry · 2013 · 94 citations · Full text

Indomethacin Analogues, Castrate-resistant Prostate Cancer, Pharmacotherapy +17

Cyclooxygenase-1-Selective Inhibitors Based on the (<i>E</i>)-2′-<i>Des</i>-methyl-sulindac Sulfide Scaffold

Andy J. Liedtke, Brenda C. Crews, Cristina M. Daniel et al. · Journal of Medicinal Chemistry · 2012 · 73 citations · Full text

Design, Synthesis, and Biological Evaluation of Novel Tri- and Tetrasubstituted Imidazoles as Highly Potent and Specific ATP-Mimetic Inhibitors of p38 MAP Kinase: Focus on Optimized Interactions with the Enzyme’s Surface-Exposed Front Region

Stefan Laufer, Dominik Hauser, David M. Domeyer et al. · Journal of Medicinal Chemistry · 2008 · 72 citations · Full text

Arylpyrrolizines as Inhibitors of Microsomal Prostaglandin E₂ Synthase-1 (mPGES-1) or as Dual Inhibitors of mPGES-1 and 5-Lipoxygenase (5-LOX)

Andy J. Liedtke, Peter R. W. E. F. Keck, Frank Lehmann et al. · Journal of Medicinal Chemistry · 2009 · 65 citations · Full text

A concise and optimized four-step approach toward 2-(aryl-)alkylsulfanyl-, 4(5)-aryl-, 5(4)-heteroaryl-substituted imidazoles using alkyl- or arylalkyl thiocyanates

Stefan Laufer, Andy J. Liedtke · Tetrahedron Letters · 2006 · 34 citations

Arylalkyl Thiocyanates, Engineering, Heterocyclic +8