FUNDC1 insufficiency sensitizes high fat diet intake-induced cardiac remodeling and contractile anomaly through ACSL4-mediated ferroptosis

Zhaohui Pei, Yandong Liu, Suqin Liu, +12

Metabolism

Metabolic SyndromeCardiomyopathyHeart FailureMetabolic DisorderCardiovascular Disease +9

Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer’s disease via inhibition of ACSL4-dependent ferroptosis

Zhiyun Zhu, Yandong Liu, Yan Gong, +11

Acta Pharmacologica Sinica

Neurodegenerative DiseasesAlzheimer's DiseaseAgingBiochemistryMitochondrial Function +9

AMPK activation enhances PPARα activity to inhibit cardiac hypertrophy via ERK1/2 MAPK signaling pathway

Rongsen Meng, Zhaohui Pei, Aixia Zhang, +7

Archives of Biochemistry and Biophysics

Cardiac MuscleSignal TransductionMolecular PhysiologyCardiovascular DiseaseCardiac Hypertrophy +10

Inhibition of advanced glycation endproduct (AGE) rescues against streptozotocin-induced diabetic cardiomyopathy: Role of autophagy and ER stress

Zhaohui Pei, Qinqin Deng, Sara A. Babcock, +3

Toxicology Letters

Metabolic SyndromeInsulin SignalingMedicineDiabetesGlycobiology +11

Double knockout of Akt2 and AMPK accentuates high fat diet-induced cardiac anomalies through a cGAS-STING-mediated mechanism

Yan Gong, Guangwei Li, Jun Tao, +6

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

ObesityMetabolic SyndromeCardiomyopathyHeart FailureMolecular Physiology +10

Empagliflozin attenuates trastuzumab-induced cardiotoxicity through suppression of DNA damage and ferroptosis

Jie Min, Lin Wu, Yandong Liu, +7

Life Sciences

InflammationDna DamageMedicineLipid PeroxidationTrastuzumab-induced Cardiotoxicity +7

Ablation of Akt2 protects against lipopolysaccharide-induced cardiac dysfunction: Role of Akt ubiquitination E3 ligase TRAF6

Yingmei Zhang, Xihui Xu, Asli F. Ceylan‐Isik, +4

Journal of Molecular and Cellular Cardiology

Cardiac MuscleCardiomyopathyHeart FailureMolecular PhysiologyCardiovascular Disease +9

Adenosine monophosphate-activated protein kinase inhibits cardiac hypertrophy through reactivating peroxisome proliferator-activated receptor-α signaling pathway

Rongsen Meng, Zhaohui Pei, Ran Yin, +6

European Journal of Pharmacology

Cardiac MuscleCardiomyopathyMolecular PhysiologyCardiovascular DiseaseMedicine +7

Angiotensin-(1–7) ameliorates myocardial remodeling and interstitial fibrosis in spontaneous hypertension: Role of MMPs/TIMPs

Zhaohui Pei, Rongsen Meng, Guangwei Li, +5

Toxicology Letters

HypertensionCardiovascular DiseasePhysiologyMyocardial RemodelingVascular Biology +6

α,β-Unsaturated aldehyde crotonaldehyde triggers cardiomyocyte contractile dysfunction: Role of TRPV1 and mitochondrial function

Zhaohui Pei, Zhiqiang Zhuang, Hanfei Sang, +7

Pharmacological Research

Molecular PharmacologyCardiomyopathyCardiac MuscleMolecular PhysiologyMitochondrial Function +9