Mapping of the Leptin Binding Sites and Design of a Leptin Antagonist

Frank Peelman, Katrien Van Beneden, Lennart Zabeau, +7

Journal of Biological Chemistry

Functional Cross-modulation between SOCS Proteins Can Stimulate Cytokine Signaling

Julie Piessevaux, Delphine Lavens, Tony Montoye, +6

Journal of Biological Chemistry

Delivering Type I Interferon to Dendritic Cells Empowers Tumor Eradication and Immune Combination Treatments

Anje Cauwels, Sandra Van Lint, Franciane Paul, +14

Cancer Research

Insulin Receptor Substrate 4 Couples the Leptin Receptor to Multiple Signaling Pathways

Joris Wauman, A. De Smet, Dominiek Catteeuw, +2

Molecular Endocrinology

Identification of Interaction Sites for Dimerization and Adapter Recruitment in Toll/Interleukin-1 Receptor (TIR) Domain of Toll-like Receptor 4

Celia Bovijn, Peter Ulrichts, A. De Smet, +4

Journal of Biological Chemistry

A safe and highly efficient tumor-targeted type I interferon immunotherapy depends on the tumor microenvironment

Anje Cauwels, Sandra Van Lint, Geneviève Garcin, +11

OncoImmunology

Reverse MAPPIT: screening for protein-protein interaction modifiers in mammalian cells

Sven Eyckerman, Irma Lemmens, Dominiek Catteeuw, +4

Nature Methods

Protein FunctionFunctional GenomicsInteractomicsReverse MappitMedicine +10

Definition of the interacting interfaces of Apobec3G and HIV-1 Vif using MAPPIT mutagenesis analysis

Delphine Lavens, Frank Peelman, José Van der Heyden, +2

Nucleic Acids Research

Selection of non-competitive leptin antagonists using a random nanobody-based approach

Lennart Zabeau, Annick Verhee, Dominiek Catteeuw, +6

Biochemical Journal

Mechanism of receptor assembly via the pleiotropic adipokine Leptin

Alexandra Tsirigotaki, Ann Dansercoer, Koen H. G. Verschueren, +12

Nature Structural & Molecular Biology

Signal TransductionBiochemistryMedicineReceptor (Biochemistry)Hypothalamic Peptide +5