Genetic analyses of isolated high‐grade pancreatic intraepithelial neoplasia (HG‐PanIN) reveal paucity of alterations in <i>TP53</i> and <i>SMAD4</i>

Waki Hosoda, Peter Chianchiano, James F. Griffin, +22

The Journal of Pathology

IPMNs with co-occurring invasive cancers: neighbours but not always relatives

Matthäus Felsenstein, Michaël Noë, David L. Masica, +19

Gut

Intraductal Papillary Mucinous Neoplasms Arise From Multiple Independent Clones, Each With Distinct Mutations

Catherine G. Fischer, Violeta Beleva Guthrie, Alicia M. Braxton, +20

Gastroenterology

Tumoral PathologyTumor HeterogeneityGeneticsSurgical PathologyEar Molding +3

Pancreatic undifferentiated carcinoma with osteoclast‐like giant cells is genetically similar to, but clinically distinct from, conventional ductal adenocarcinoma

Claudio Luchini, Antonio Pea, Gemma Lionheart, +17

The Journal of Pathology

PathologyPure UcogcTumor BiologyPdac VariantOsteoclast‐like Giant Cells +16

Genetic Analysis of Small Well-differentiated Pancreatic Neuroendocrine Tumors Identifies Subgroups With Differing Risks of Liver Metastases

Antonio Pea, Jun Yu, Luigi Marchionni, +22

Annals of Surgery

Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Wenjie Huang, Bernat Navarro-Serer, Yea Ji Jeong, +33

Cancer Research

Collective InvasionPancreatic CancerTumor HeterogeneityMedicinePdac Organoids +13

Amyloid β and Tau Alzheimer’s disease related pathology is reduced by Toll-like receptor 9 stimulation

Henrieta Scholtzova, Peter Chianchiano, Jason Pan, +3

Acta Neuropathologica Communications

Amyloid βImmunologyImmune RegulationNeurochemical BiomarkersInnate Immunity +27

PD-1, PD-L1, and CD163 in pancreatic undifferentiated carcinoma with osteoclast-like giant cells: expression patterns and clinical implications

Claudio Luchini, Jérôme Cros, Antonio Pea, +22

Human Pathology

Osteoclast-like Giant CellsPancreatic CancerPancreatic Undifferentiated CarcinomaMedicineExpression Patterns +5

Single‐cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions

Yuko Kuboki, Catherine G. Fischer, Violeta Beleva Guthrie, +18

The Journal of Pathology

Distinction of intrahepatic metastasis from multicentric carcinogenesis in multifocal hepatocellular carcinoma using molecular alterations

Peter Chianchiano, Maryam Kherad Pezhouh, Amy Kim, +8

Human Pathology

Tumor BiologyHepatologyHepatocellular CarcinomaMedicineHepatobiliary Tumor +11