Modulation of Human CYP19A1 Activity by Mutant NADPH P450 Oxidoreductase

Amit V. Pandey, Petra Kempná, Gaby Hofer, +2

Molecular Endocrinology

Reductive StressNadph P450 OxidoreductaseBiochemistryMitochondrial FunctionNatural Sciences +9

Metformin Inhibits Human Androgen Production by Regulating Steroidogenic Enzymes HSD3B2 and CYP17A1 and Complex I Activity of the Respiratory Chain

Andrea Hirsch, Dagmar Hahn, Petra Kempná, +4

Endocrinology

Polycystic Ovary SyndromeFemale Reproductive FunctionOxidative StressMetabolic SyndromeAmp-activated Protein Kinase +20

Concentrations of various arachidonic acid metabolites in menstrual fluid are associated with menstrual pain and are influenced by hormonal contraceptives

Ch. Bieglmayer, Gaby Hofer, Ch. Kainz, +3

Gynecological Endocrinology

Pioglitazone Inhibits Androgen Production in NCI-H295R Cells by Regulating Gene Expression of CYP17 and HSD3B2

Petra Kempná, Gaby Hofer, Primus E. Mullis, +1

Molecular Pharmacology

Characterization of a novel CYP19A1 (aromatase) R192H mutation causing virilization of a 46,XX newborn, undervirilization of the 46,XY brother, but no virilization of the mother during pregnancies

Nadia Bouchoucha, Dinane Samara‐Boustani, Amit V. Pandey, +5

Molecular and Cellular Endocrinology

Genome InstabilityCytogeneticsGenetic DisorderGeneticsGynecology +11

Human adrenal corticocarcinoma NCI-H295R cells produce more androgens than NCI-H295A cells and differ in 3β-hydroxysteroid dehydrogenase type 2 and 17,20 lyase activities

Elika Samandari, Petra Kempná, Jean‐Marc Nuoffer, +3

Journal of Endocrinology

Deletion of P399_E401 in NADPH cytochrome P450 oxidoreductase results in partial mixed oxidase deficiency

Christa E. Flück, Delphine Mallet, Gaby Hofer, +5

Biochemical and Biophysical Research Communications

BiochemistryNatural SciencesGeneticsHeme DegradationBiochemical Genetics +6

Differential Regulation of Human 3β-Hydroxysteroid Dehydrogenase Type 2 for Steroid Hormone Biosynthesis by Starvation and Cyclic Amp Stimulation: Studies in the Human Adrenal NCI-H295R Cell Model

Sameer S. Udhane, Petra Kempná, Gaby Hofer, +2

PLoS ONE

Impact of Differential P450c17 Phosphorylation by cAMP Stimulation and by Starvation Conditions on Enzyme Activities and Androgen Production in NCI-H295R Cells

Petra Kempná, Andrea Hirsch, Gaby Hofer, +2

Endocrinology

Retinoic acid receptor beta and angiopoietin-like protein 1 are involved in the regulation of human androgen biosynthesis

Sameer S. Udhane, Amit V. Pandey, Gaby Hofer, +2

Scientific Reports