Lucy Kirkham-McCarthy

CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide

Mark E. Gurney, Arwen Stikvoort, Emma Nolan et al. · Haematologica · 2020 · 110 citations · Full text

Life Sciences, Immunology, Oncology +17

A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington’s disease mice

Núria Suelves, Lucy Kirkham-McCarthy, Robert S. Lahue et al. · Scientific Reports · 2017 · 76 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Histone Deacetylase Complexes Promote Trinucleotide Repeat Expansions

Kim Debacker, Aisling Frizzell, Olive Gleeson et al. · PLoS Biology · 2012 · 61 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model

Alessandro Natoni, Mariah L. Farrell, Sophie Harris et al. · Haematologica · 2019 · 54 citations · Full text

Medicine, Oncology, Pharmacology +16

E-selectin ligands recognised by HECA452 induce drug resistance in myeloma, which is overcome by the E-selectin antagonist, GMI-1271

Alessandro Natoni, Theodore A Smith, Niamh Keane et al. · Leukemia · 2017 · 42 citations · Full text

Medicine, Cancer Biology, Oncology +11