Iain J. McFadyen

Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

Kimberly J. Hassett, Kerry E. Benenato, Eric Jacquinet et al. · Molecular Therapy — Nucleic Acids · 2019 · 888 citations · Full text

Pharmacy, Immunology, Pharmaceutics +17

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

Staci Sabnis, E. Sathyajith Kumarasinghe, Timothy Salerno et al. · Molecular Therapy · 2018 · 794 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +16

mRNA structure regulates protein expression through changes in functional half-life

David Mauger, B. Joseph Cabral, Vladimir Presnyak et al. · Proceedings of the National Academy of Sciences · 2019 · 559 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +17

Human 5′ UTR design and variant effect prediction from a massively parallel translation assay

Paul Sample, Ban Wang, David W. Reid et al. · Nature Biotechnology · 2019 · 459 citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +17

A Selective Matrix Metalloprotease 12 Inhibitor for Potential Treatment of Chronic Obstructive Pulmonary Disease (COPD): Discovery of (<i>S</i>)-2-(8-(Methoxycarbonylamino)dibenzo[<i>b</i>,<i>d</i>]furan-3-sulfonamido)-3-methylbutanoic acid (MMP408)

Wei Li, Jianchang Li, Yuchuan Wu et al. · Journal of Medicinal Chemistry · 2009 · 104 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13