A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

Patrick M. Nolan, Jo Peters, Mark Strivens, +41

Nature Genetics

Knockout MouseTransgenic Mouse ModelsGeneticsPhenotype-driven Mutagenesis ProgrammeGene Characterization +9

A gene-driven ENU-based approach to generating an allelic series in any gene

Mohamed Mohideen Quwailid, Alison Hugill, Neil Dear, +27

Mammalian Genome

BiologyAllelic SeriesFunctional GenomicsEngineeringGenetics +12

Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features

Valter Tucci, Tjitske Kleefstra, Andrea Hardy, +33

Journal of Clinical Investigation

Brain DevelopmentGeneticsNeurochemical BiomarkersDisease Gene IdentificationSynaptic Signaling +23

Implementation of a large-scale ENU mutagenesis program: towards increasing the mouse mutant resource

Patrick M. Nolan, Jo Peters, Lucie Vizor, +18

Mammalian Genome

Knockout MouseGeneticsMolecular BiologyGenetic EngineeringMolecular Genetics +5

Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development

Tom R. Webb, Sally H. Cross, Lisa McKie, +5

Journal of Cell Science

Molecular BiologyMolecular GeneticsProtein ExpressionDiphtheria ToxinJ-domain Protein +14

A mutation in Af4 is predicted to cause cerebellar ataxia and cataracts in the robotic mouse.

Adrian M. Isaacs, Peter L. Oliver, Emma Jones, +11

PubMed

Knockout MouseDevelopmental BiologyOphthalmologyExperimental OphthalmologyRobotic Mouse +9

Novel phenotypes identified by plasma biochemical screening in the mouse

Tertius Hough, Patrick M. Nolan, Vicky Tsipouri, +19

Mammalian Genome

Knockout MouseIn Vivo SystemImmunologyNovel PhenotypesEndocrinology +2

A Mutation in<i>Af4</i>Is Predicted to Cause Cerebellar Ataxia and Cataracts in the Robotic Mouse

Adrian M. Isaacs, Peter L. Oliver, Emma Jones, +12

Journal of Neuroscience

Knockout MouseMolecular NeuroscienceDevelopmental BiologyOphthalmologyGenetics +12

HIF–VEGF Pathways Are Critical for Chronic Otitis Media in Junbo and Jeff Mouse Mutants

Michael Cheeseman, Hayley E. Tyrer, Debbie Williams, +12

PLoS Genetics

Inducible Knockout of Mouse <i>Zfhx3</i> Emphasizes Its Key Role in Setting the Pace and Amplitude of the Adult Circadian Clock

Ashleigh G. Wilcox, Lucie Vizor, Michael Parsons, +2

Journal of Biological Rhythms

Key RoleTamoxifen TreatmentGeneticsHomeostatic MechanismAdult Circadian Clock +22