Sheerin Shahidi-Latham

Discovery of (<i>S</i>)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1<i>H</i>-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1<i>H</i>)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development

James F. Blake, Michael Burkard, Jocelyn Chan et al. · Journal of Medicinal Chemistry · 2016 · 158 citations · Full text

Medicine, Oncology, Pharmacology +17

Structure of the essential inner membrane lipopolysaccharide–PbgA complex

Thomas Clairfeuille, Kerry R. Buchholz, Qingling Li et al. · Nature · 2020 · 100 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors

Mark Merchant, John G. Moffat, Gabriele Schaefer et al. · PLoS ONE · 2017 · 93 citations · Full text

Medicine, Cancer Biology, Oncology +17

METASPACE: A community-populated knowledge base of spatial metabolomes in health and disease

Theodore Alexandrov, Katja Ovchinnikova, Andrew Palmer et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 89 citations · Full text

Life Sciences, Biochemistry, Bioinformatics +17

Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma

Laurent Salphati, Bruno Alicke, Timothy P. Heffron et al. · Drug Metabolism and Disposition · 2016 · 52 citations

Medicine, Oncology, Pharmacology +17