Quentin M. R. Gibaut

Programming inactive RNA-binding small molecules into bioactive degraders

Yuquan Tong, Yeongju Lee, Xiaohui Liu et al. · Nature · 2023 · 132 citations · Full text

<b>Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of <i>QSOX1</i> mRNA</b>

Yuquan Tong, Quentin M. R. Gibaut, Warren B. Rouse et al. · Journal of the American Chemical Society · 2022 · 64 citations · Full text

Decreasing the intrinsically disordered protein α-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera

Yuquan Tong, Peiyuan Zhang, Xueyi Yang et al. · Proceedings of the National Academy of Sciences · 2024 · 39 citations · Full text

Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion

Quentin M. R. Gibaut, Yoshihiro Akahori, Jessica A. Bush et al. · Journal of the American Chemical Society · 2022 · 31 citations · Full text

Low-Molecular Weight Small Molecules Can Potently Bind RNA and Affect Oncogenic Pathways in Cells

Blessy M. Suresh, Yoshihiro Akahori, Amirhossein Taghavi et al. · Journal of the American Chemical Society · 2022 · 25 citations · Full text