J.-P. Marquette

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

Baptiste Ronan, Odile Flamand, Lionel Vescovi et al. · Nature Chemical Biology · 2014 · 476 citations

Cell Autophagy, Signal Transduction, Cell Trafficking +10

Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (IDH1) via Disruption of a Metal Binding Network by an Allosteric Small Molecule

Gejing Deng, Junqing Shen, Ming Yin et al. · Journal of Biological Chemistry · 2014 · 135 citations · Full text

The 2.4-Å crystal structure of the penicillin-resistant penicillin-binding protein PBP5fm from Enterococcus faecium in complex with benzylpenicillin

E. Sauvage, Frédéric Kerff, E. Fonzé et al. · Cellular and Molecular Life Sciences · 2002 · 97 citations · Full text

Antimicrobial Resistance Gene, Health Sciences, Biochemistry +12

Automated harvesting and processing of protein crystals through laser photoablation

U. Zander, Guillaume Hoffmann, Irina Cornaciu et al. · Acta Crystallographica Section D Structural Biology · 2016 · 97 citations · Full text

X-ray Crystallography, Crystal Structure, Microscopy +18

SAR and X-ray. A New Approach Combining Fragment-Based Screening and Rational Drug Design:  Application to the Discovery of Nanomolar Inhibitors of Src SH2

Dominique Lesuisse, Gudrun Lange, Pierre Deprez et al. · Journal of Medicinal Chemistry · 2002 · 90 citations · Full text