Cloning and Sequencing of the Cellular–Viral Junctions from the Human Adenovirus Type 5 Transformed 293 Cell Line

Nathalie Louis, Carole Evelegh, Frank L. Graham

Virology

Virus StructureViral ReplicationTransformed 293Cellular–viral JunctionsViral Polymerase Mechanism +7

Sequences in E1A proteins of human adenovirus 5 required for cell transformation, repression of a transcriptional enhancer, and induction of proliferating cell nuclear antigen

Tony N. Jelsma, John A. Howe, Joe S. Mymryk, +3

Virology

Transcriptional RegulationViral ReplicationImmunologyE1a ProteinsVirology +8

Enabling topical immunization via microporation: a novel method for pain-free and needle-free delivery of adenovirus-based vaccines

Jonathan L. Bramson, Kelley Dayball, Carole Evelegh, +3

Gene Therapy

VaccinationNanomedicineAdenovirus-based VaccinesEngineeringImmunology +8

A High-Efficiency Cre/loxP-Based System for Construction of Adenoviral Vectors

Robin J. Parks, Derek T. Cummings, Carole Evelegh, +2

Human Gene Therapy

Viral ReplicationEngineeringImmunologyMolecular BiologyGene Delivery +15

Development of a FLP/frt System for Generating Helper-Dependent Adenoviral Vectors

Philip Ng, Cindy Beauchamp, Carole Evelegh, +2

Molecular Therapy

Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration

Robin J. Parks, Carole Evelegh, Frank L. Graham

Gene Therapy

Alternative SerotypesNeurovirologyRepeat Vector AdministrationImmunologyAntiviral Therapy +5

An Enhanced System for Construction of Adenoviral Vectors by the Two-Plasmid Rescue Method

Robin J. Parks, Derek T. Cummings, Carole Evelegh, +1

Human Gene Therapy

Viral ReplicationEngineeringReverse GeneticsSynthetic VirologyMolecular Biology +19

Use of deletion and point mutants spanning the coding region of the adenovirus 5 E1A gene to define a domain that is essential for transcriptional activation

Tony N. Jelsma, John A. Howe, Carole Evelegh, +5

Virology

Transcriptional RegulationNatural SciencesPoint MutantsMolecular BiologyAdenovirus 5 +7

Preclinical evaluation of a MAGE-A3 vaccination utilizing the oncolytic Maraba virus currently in first-in-human trials

Jonathan Pol, Sergio A. Acuña, Beta Yadollahi, +24

OncoImmunology

The Polyfunctionality of Human Memory CD8+ T Cells Elicited by Acute and Chronic Virus Infections Is Not Influenced by Age

Alina Lelic, Chris P. Verschoor, Mario Ventresca, +6

PLoS Pathogens