The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL

Maroun Bou Khalil, Meenakshi Sundaram, Hongyu Zhang, +8

Journal of Lipid Research

PKR and PKR-like Endoplasmic Reticulum Kinase Induce the Proteasome-dependent Degradation of Cyclin D1 via a Mechanism Requiring Eukaryotic Initiation Factor 2α Phosphorylation

Jennifer F. Raven, Dionissios Baltzis, Shuo Wang, +4

Journal of Biological Chemistry

Proteasome-dependent DegradationCyclin D1ApoptosisProteasomeCell Cycle +14

A Novel Function of eIF2α Kinases as Inducers of the Phosphoinositide-3 Kinase Signaling Pathway

Shirin Kazemi, Zineb Mounir, Dionissios Baltzis, +6

Molecular Biology of the Cell

Environmental StressCell DeathCellular PhysiologyProtein SynthesisSignaling Pathway +17

Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation

Jennifer F. Raven, Virginie Williams, Shuo Wang, +4

Cell Cycle

Breast OncologyImmunologyCancer BiologyAnti-tumor FunctionTumor Biology +17

The eIF2α kinases inhibit vesicular stomatitis virus replication independently of eIF2 phosphorylation.

Jothi Krishnamoorthy, Zineb Mounir, Jennifer F. Raven, +1

Cell Cycle

Interferons induce tyrosine phosphorylation of the eIF2α kinase PKR through activation of Jak1 and Tyk2

Qiaozhu Su, Shuo Wang, Dionissios Baltzis, +5

EMBO Reports

Tyrosine PhosphorylationSignal TransductionSignaling PathwayCell RegulationReceptor Tyrosine Kinase +8

The Catalytic Activity of the Eukaryotic Initiation Factor-2α Kinase PKR Is Required to Negatively Regulate Stat1 and Stat3 via Activation of the T-cell Protein-tyrosine Phosphatase

Shuo Wang, Jennifer F. Raven, Dionissios Baltzis, +5

Journal of Biological Chemistry

Protein Kinase PkrImmunologyTranscriptional RegulationSignaling PathwayCell Regulation +15

Stat1 Phosphorylation Determines Ras Oncogenicity by Regulating p27Kip1

Shuo Wang, Jennifer F. Raven, Joan E. Durbin, +1

PLoS ONE

A Fusion of GMCSF and IL-21 Initiates Hypersignaling Through the IL-21Rα Chain With Immune Activating and Tumoricidal Effects In Vivo

Patrick Williams, Moutih Rafei, Manaf Bouchentouf, +6

Molecular Therapy

Corticosteroids for sore throat: a clinical practice guideline

Bert Aertgeerts, Thomas Agoritsas, Reed Siemieniuk, +18

BMJ

Pain DisordersPain MedicineEvidence-based MedicineOtorhinolaryngologyTonsillectomy +18