Shana Posy

Improving Accuracy, Diversity, and Speed with Prime Macrocycle Conformational Sampling

Dan Sindhikara, Steven A. Spronk, Tyler Day et al. · Journal of Chemical Information and Modeling · 2017 · 115 citations

Life Sciences, Bioinformatics, Medicinal Chemistry +13

The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity

Benjamin A. Seigal, William H. Connors, Andrew W. Fraley et al. · Journal of Medicinal Chemistry · 2015 · 86 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Trends in Kinase Selectivity: Insights for Target Class-Focused Library Screening

Shana Posy, Mark A. Hermsmeier, Wayne Vaccaro et al. · Journal of Medicinal Chemistry · 2010 · 80 citations

Pharmacy, Chemical Biology, Medicinal Chemistry +15

Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9)

Christopher P. Mussari, Dharmpal S. Dodd, Ratna Kumar Sreekantha et al. · ACS Medicinal Chemistry Letters · 2020 · 41 citations · Full text

Life Sciences, Immunology, Pharmacology +16

Discovery of Non-Nucleotide Small-Molecule STING Agonists <i>via</i> Chemotype Hybridization

Emily C. Cherney, Liping Zhang, Julian B. Lo et al. · Journal of Medicinal Chemistry · 2022 · 34 citations · Full text

Medicine, Oncology, Pharmacology +16