Matthew Lombardo

Design and Synthesis of Prolylcarboxypeptidase (PrCP) Inhibitors To Validate PrCP As A Potential Target for Obesity

Changyou Zhou, Margareta Garcia-Calvo, Shirly Pinto et al. · Journal of Medicinal Chemistry · 2010 · 51 citations · Full text

Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists

Jason M. Cox, Hong D. Chu, Mariappan V. Chelliah et al. · ACS Medicinal Chemistry Letters · 2016 · 32 citations · Full text

Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects

Matthew Lombardo, Kate Bender, Clare London et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 24 citations · Full text

Drug Target, Mechanism-based Pharmacodynamic Effects, Biochemistry +7

Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

Songnian Lin, Matthew Lombardo, Sunita Malkani et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 21 citations · Full text

Biochemistry, Medicine, Receptor Tyrosine Kinase +8

Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes

Jonathan E. Wilson, Ravi Kurukulasuriya, Christopher J. Sinz et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 15 citations · Full text

Diabetes Management, Medicine, Diabetes +4