Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two phase 1 studies

Reuben Benjamin, Charlotte Graham, Deborah Yallop, +135

The Lancet

Hematological MalignancyCell TherapyTransplantationMedicineHematology +7

Prevalence of the Activating JAK2 Tyrosine Kinase Mutation V617F in the Budd–Chiari Syndrome

Raj Patel, Nicholas Lea, Michael A. Heneghan, +10

Gastroenterology

Budd–chiari SyndromeGenetic DisorderGeneticsPathogenesisPathology +3

Obecabtagene Autoleucel in Adults with B-Cell Acute Lymphoblastic Leukemia

Claire Roddie, Karamjeet Sandhu, Eleni Tholouli, +28

New England Journal of Medicine

UCART19, a first-in-class allogeneic anti-CD19 chimeric antigen receptor T-cell therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia (CALM): a phase 1, dose-escalation trial

Reuben Benjamin, Nitin Jain, Marcela V. Maus, +92

The Lancet Haematology

Hematological MalignancyLymphoid NeoplasiaCell TherapyMedicineImmunology +8

Interaction with Vascular Endothelium Enhances Survival in Primary Chronic Lymphocytic Leukemia Cells via NF-κB Activation and <i>De novo</i> Gene Transcription

Andrea G.S. Buggins, Chris Pepper, Piers Patten, +9

Cancer Research

Preliminary Data on Safety, Cellular Kinetics and Anti-Leukemic Activity of UCART19, an Allogeneic Anti-CD19 CAR T-Cell Product, in a Pool of Adult and Pediatric Patients with High-Risk CD19+ Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia

Reuben Benjamin, Charlotte Graham, Deborah Yallop, +23

Blood

Evidence for a macromolecular complex in poor prognosis CLL that contains CD38, CD49d, CD44 and MMP‐9

Andrea G.S. Buggins, Ana Levi, Satyen H. Gohil, +5

British Journal of Haematology

Early FDG-PET response predicts CAR-T failure in large B-cell lymphoma

Andrea Kühnl, Claire Roddie, Amy A. Kirkwood, +15

Blood Advances

Lymphoid NeoplasiaMedicineMalignant Blood DisorderImmunologyPathology +7

Induction therapy with the MATRix regimen in patients with newly diagnosed primary diffuse large B‐cell lymphoma of the central nervous system – an international study of feasibility and efficacy in routine clinical practice

Elisabeth Schorb, Christopher P. Fox, Benjamin Kasenda, +16

British Journal of Haematology

Clinical and prognostic significance of small paroxysmal nocturnal hemoglobinuria clones in myelodysplastic syndrome and aplastic anemia

Bruno Fattizzo, Robin Ireland, Alan Dunlop, +12

Leukemia