Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy

Michaela Yuen, Sarah A. Sandaradura, James J. Dowling, +54

Journal of Clinical Investigation

MechanobiologyThin FilamentsSystems BiologyDevelopmental BiologyEngineering +13

Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization

Laura T. Donlin, Christian Andresen, Steffen Just, +12

Genes & Development

Molecular RegulationEpigenetic ChangeMolecular BiologyEpigeneticsCellular Physiology +14

Nebulin regulates actin filament lengths by a stabilization mechanism

Christopher T. Pappas, Paul A. Krieg, Carol C. Gregorio

The Journal of Cell Biology

EngineeringCytoskeletonMechanotransductionCellular PhysiologyActin Filament Lengths +17

Leiomodin-2 is an antagonist of tropomodulin-1 at the pointed end of the thin filaments in cardiac muscle

Takehiro Tsukada, Christopher T. Pappas, Natalia Moroz, +3

Journal of Cell Science

Cardiac MuscleMolecular BiologyCytoskeletonMechanotransductionCardiovascular Function +21

Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function

Henk Granzier, Kirk R. Hutchinson, Paola Tonino, +8

Proceedings of the National Academy of Sciences

Nebulin Interacts with CapZ and Regulates Thin Filament Architecture within the Z-Disc

Christopher T. Pappas, Nandini Bhattacharya, John A. Cooper, +1

Molecular Biology of the Cell

Assembled CapzCell AdhesionMolecular BiologyCytoskeletonBarbed Ends +14

Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality

Christopher T. Pappas, Rachel M. Mayfield, Christine Henderson, +10

Proceedings of the National Academy of Sciences

HSPB7 is indispensable for heart development by modulating actin filament assembly

Tongbin Wu, Yongxin Mu, Julius Bogomolovas, +8

Proceedings of the National Academy of Sciences

Cardiac MuscleHeart FailureMolecular RegulationCytoskeletonBiomedical Engineering +21

Construction and Validation of the <i>Rhodobacter sphaeroides</i> 2.4.1 DNA Microarray: Transcriptome Flexibility at Diverse Growth Modes

Christopher T. Pappas, Jakub P. Sram, Oleg V. Moskvin, +7

Journal of Bacteriology

Molecular BiologyTranscriptomics TechnologyGenomicsBiosynthesisBioenergetics +16

Mutation‐specific effects on thin filament length in thin filament myopathy

Josine M. de Winter, Barbara Joureau, Eun‐Jeong Lee, +20

Annals of Neurology