Nancy E. Sealover

Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Elizabeth M. Terrell, David Durrant, Daniel A. Ritt et al. · Molecular Cell · 2019 · 120 citations · Full text

Medicine, Cancer Biology, Molecular Biology +16

Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer

Patricia L. Theard, Erin Sheffels, Nancy E. Sealover et al. · eLife · 2020 · 70 citations · Full text

Medicine, Oncology, Pharmacology +17

Oncogenic RAS isoforms show a hierarchical requirement for the guanine nucleotide exchange factor SOS2 to mediate cell transformation

Erin Sheffels, Nancy E. Sealover, Chenyue Wang et al. · Science Signaling · 2018 · 58 citations · Full text

Medicine, Genetics, Molecular Biology +17

Anchorage-independent growth conditions reveal a differential SOS2 dependence for transformation and survival in <i>RAS</i>-mutant cancer cells

Erin Sheffels, Nancy E. Sealover, Patricia L. Theard et al. · Small GTPases · 2019 · 33 citations · Full text

Medicine, Molecular Genetics, Oncology +16

SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status

Brianna R. Daley, Heidi M. Vieira, Chaitra Rao et al. · Proceedings of the National Academy of Sciences · 2023 · 28 citations · Full text

Medicine, Oncology, Pharmacology +17