Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

Ali Salanti, Thomas Mandel Clausen, Mette Ø. Agerbæk, +32

Cancer Cell

Drug TargetingGlycobiologyHuman CancerAnti-cancer AgentMedicine +3

Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity

Cyrielle Fougeroux, Louise Goksøyr, Manja Idorn, +44

Nature Communications

The WSXWS Motif in Cytokine Receptors Is a Molecular Switch Involved in Receptor Activation: Insight from Structures of the Prolactin Receptor

Robert Dagil, Maiken J. Knudsen, Johan G. Olsen, +6

Structure

InflammationCytokineSignal TransductionG Protein-coupled ReceptorImmunology +10

Gentamicin Binds to the Megalin Receptor as a Competitive Inhibitor Using the Common Ligand Binding Motif of Complement Type Repeats

Robert Dagil, Charlotte O’Shea, Anders Nykjær, +2

Journal of Biological Chemistry

Complement Type RepeatsSignal TransductionG Protein-coupled ReceptorMedicineImmunology +9

Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein

Sara R. Bang-Christensen, Rasmus S. Pedersen, Marina Ayres Pereira, +20

Cells

Neuro-oncologyGlioma CtcsCirculating Glioma CellsMalignant DiseaseMedicine +12

Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding

Kaituo Wang, Robert Dagil, Thomas Lavstsen, +15

Nature Communications

Molecular DockingBiochemistryProtein AssemblyProtein FoldingMolecular Insight +12

The TH1 cell lineage-determining transcription factor T-bet suppresses TH2 gene expression by redistributing GATA3 away from TH2 genes

Arnulf Hertweck, Maria Vila de Mucha, Paul R. Barber, +5

Nucleic Acids Research

Two-Component Nanoparticle Vaccine Displaying Glycosylated Spike S1 Domain Induces Neutralizing Antibody Response against SARS-CoV-2 Variants

Linda van Oosten, Jort J. Altenburg, Cyrielle Fougeroux, +26

mBio

First-in-human use of a modular capsid virus-like vaccine platform: an open-label, non-randomised, phase 1 clinical trial of the SARS-CoV-2 vaccine ABNCoV2

Merel J Smit, Adam F. Sander, Maud B P A Ariaans, +63

The Lancet Microbe

IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties

Robert Dagil, Neil J. Ball, R.W. Ogrodowicz, +6

Nucleic Acids Research