Inhibition of the Phosphatidylinositol 3-Kinase/Akt Pathway by Inositol Pentakisphosphate Results in Antiangiogenic and Antitumor Effects

Tania Maffucci, Enza Piccolo, Albana Cumashi, +10

Cancer Research

Synthetic lactulose amines: novel class of anticancer agents that induce tumor-cell apoptosis and inhibit galectin-mediated homotypic cell aggregation and endothelial cell morphogenesis

Gabriel A. Rabinovich, Albana Cumashi, Germán A. Bianco, +7

Glycobiology

The mechanism involved in the regulation of phospholipase Cγ1 activity in cell migration

Enza Piccolo, Pasquale F. Innominato, Maria A. Mariggiò, +3

Oncogene

Signal TransductionPhospholipase Cγ1 ActivityCell TraffickingImmunologyCell Migration +7

Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway

Enza Piccolo, Sara Vignati, Tania Maffucci, +8

Oncogene

Signal TransductionApoptosisCell DeathInositol Pentakisphosphate PromotesCellular Biochemistry +5

LGALS3BP, lectin galactoside-binding soluble 3 binding protein, induces vascular endothelial growth factor in human breast cancer cells and promotes angiogenesis

Enza Piccolo, Nicola Tinari, Daniela Semeraro, +14

Journal of Molecular Medicine

Tumor BiologyAngiogenesisMedicineImmunologyGalactoside-binding Soluble 3 +11

Synthetic inhibitors of galectin-1 and -3 selectively modulate homotypic cell aggregation and tumor cell apoptosis.

Ida Iurisci, Albana Cumashi, Andrei A. Sherman, +9

PubMed

Secreted Gal-3BP is a novel promising target for non-internalizing Antibody–Drug Conjugates

Francesco Giansanti, Emily Capone, Sara Ponziani, +13

Journal of Controlled Release

Protein SecretionImmunologyImmunotherapyNon-internalizing Antibody–drug ConjugatesHumanized 1959 +15

Strain- and Sex-Dependent Circadian Changes in Abcc2 Transporter Expression: Implications for Irinotecan Chronotolerance in Mouse Ileum

Alper Okyar, Enza Piccolo, Constance Ahowesso, +7

PLoS ONE

Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling

Alper Okyar, Swati A. Kumar, Elisabeth Filipski, +11

Scientific Reports

Prognostic relevance of LGALS3BP in human colorectal carcinoma

Enza Piccolo, Nicola Tinari, Domenica D'Addario, +9

Journal of Translational Medicine