RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response

Katelyn M. Green, M. Rebecca Glineburg, Michael G. Kearse, +6

Nature Communications

CGG Repeat-Associated Non-AUG Translation Utilizes a Cap-Dependent Scanning Mechanism of Initiation to Produce Toxic Proteins

Michael G. Kearse, Katelyn M. Green, Amy Krans, +4

Molecular Cell

Protein FunctionProtein ExpressionNatural SciencesProtein BiosynthesisCap-dependent Scanning Mechanism +8

Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors

Michael G. Kearse, Daniel Goldman, Jiou Choi, +7

Genes & Development

<scp>DDX</scp> 3X and specific initiation factors modulate <i> <scp>FMR</scp> 1 </i> repeat‐associated non‐AUG‐initiated translation

Alexander E. Linsalata, Fang He, Ahmed M. Malik, +9

EMBO Reports

The RNA helicase DHX36–G4R1 modulates C9orf72 GGGGCC hexanucleotide repeat–associated translation

Yi‐Ju Tseng, Siara N. Sandwith, Katelyn M. Green, +12

Journal of Biological Chemistry

High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation

Katelyn M. Green, Udit Sheth, Brittany N. Flores, +6

Journal of Biological Chemistry

Drug TargetMolecular BiologyNeurochemical BiomarkersChemical BiologyRepeat-associated Non-aug Translation +14

Pro-inflammatory cytokines downregulate Hsp27 and cause apoptosis of human retinal capillary endothelial cells

Rooban B. Nahomi, Allison Palmer, Katelyn M. Green, +2

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

InflammationCytokineOcular DiseaseOphthalmologyPro-inflammatory Cytokines +8

A specific phosphorylation regulates the protective role of αA-crystallin in diabetes

Anne Ruebsam, Jennifer E. Dulle, Angela M. Myers, +5

JCI Insight

Ocular DiseaseNeuroretinal DegenerationInsulin SignalingDiabetic RetinopathyDiabetic Neuropathy +19

SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity

Indranil Malik, Yi‐Ju Tseng, Shannon E. Wright, +4

EMBO Molecular Medicine

Non-canonical initiation factors modulate repeat-associated non-AUG translation

Katelyn M. Green, Shannon L. Miller, Indranil Malik, +1

Human Molecular Genetics

Transcriptional RegulationSystems BiologyMedicineNatural SciencesMolecular Biology +9