Hiroyasu Ohtaka

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Publications

Citations

537

H-Index

Active since

2002

Affiliations

Chiba Institute of Science(Current)

Johns Hopkins University

Hiroyasu Ohtaka is an author at Chiba Institute of Science specializing in enzyme inhibition, drug resistance mutations, and antiviral resistance mutations.

Publications per year

2002–2020

Publications

Compensating Enthalpic and Entropic Changes Hinder Binding Affinity Optimization

Virginie Lafont, Anthony A. Armstrong, Hiroyasu Ohtaka et al. · Chemical Biology & Drug Design · 2007 · 191 citations

Pharmacy, Biochemistry, Medicinal Chemistry +15

Multidrug Resistance to HIV-1 Protease Inhibition Requires Cooperative Coupling between Distal Mutations

Hiroyasu Ohtaka, Arne Schön, Ernesto Freire · Biochemistry · 2003 · 142 citations

Life Sciences, Molecular Biology, Pharmacology +17

Overcoming drug resistance in HIV‐1 chemotherapy: The binding thermodynamics of Amprenavir and TMC‐126 to wild‐type and drug‐resistant mutants of the HIV‐1 protease

Hiroyasu Ohtaka, Adrián Velázquez‐Campoy, Dong Xie et al. · Protein Science · 2002 · 110 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor

Seisuke Mimori, Hiroyasu Ohtaka, Yukari Koshikawa et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 70 citations

Medicine, Neurobiology, Neuroscience +17

Diffusion-Facilitated Direct Determination of Intrinsic Parameters for Rapid Photoinduced Bimolecular Electron-Transfer Reactions in Nonpolar Solvents

Andrew D. Scully, Hiroyasu Ohtaka, Makoto Takezaki et al. · The Journal of Physical Chemistry A · 2015 · 13 citations

Natural Sciences, Biophysics, Chemistry +17

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