Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers

Jacob L. Glass, Duane C. Hassane, Bas J. Wouters, +18

Cancer Discovery

Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity

Hiroyoshi Kunimoto, Cem Meydan, Abbas Nazir, +11

Cancer Cell

ChromatinGenome InstabilityChromatin RemodelingEpigenetic ChangeGenetics +9

Reactivation of hepatitis B in a patient with Crohn’s disease treated using infliximab

Keisuke Ojiro, Makoto Naganuma, Hirotoshi Ebinuma, +6

Journal of Gastroenterology

Autoimmune DiseaseCrohn ’Viral HepatitisImmunologyGastroenterology +4

Impaired hematopoietic differentiation of RUNX1-mutated induced pluripotent stem cells derived from FPD/AML patients

Masatoshi Sakurai, Hiroyoshi Kunimoto, Naohide Watanabe, +18

Leukemia

Induced Pluripotent Stem CellDevelopmental BiologyFpd/aml PatientsMedicineStem Cell Mobilization +6

Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells

Hiroyoshi Kunimoto, Yumi Fukuchi, Masatoshi Sakurai, +4

Scientific Reports

OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy

Koichi Murakami, Daisuke Kurotaki, Wataru Kawase, +20

Cell Reports

O-linked N-acetylglucosamineMitophagyMitochondrial QualityCell DivisionStem Cell Mobilization +13

Effect of Early Posttransplantation Tacrolimus Concentration on the Development of Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation from Unrelated Donors

Takehiko Mori, Jun Kato, Takayuki Shimizu, +6

Biology of Blood and Marrow Transplantation

ImmunohematologyGvhd ProphylaxisImmunologyTransplantation MedicineWhole Blood Concentration +17

Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells

Hiroyoshi Kunimoto, Anna Sophia McKenney, Cem Meydan, +10

Blood

Aberrant <i>EVI1</i> splicing contributes to <i>EVI1</i>-rearranged leukemia

Atsushi Tanaka, Taizo A. Nakano, Masaki Nomura, +28

Blood

Hematological MalignancyChromatinTranscriptional RegulationMixed-phenotype Acute LeukemiaGenetics +11

Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia

Katherine Knorr, Jahan Rahman, Caroline Erickson, +23

Nature Cancer