Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines

Tomonori Nochi, Yoshikazu Yuki, Haruko Takahashi, +14

Nature Materials

VaccinationNanomedicineCross-protectionAdjuvant-free Intranasal VaccinesImmunology +4

Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination

Tomonori Nochi, Hidenori Takagi, Yoshikazu Yuki, +11

Proceedings of the National Academy of Sciences

Humoral ResponseImmunologyImmunodominanceAntigen ProcessingImmunotherapy +19

Comprehensive Gene Expression Profiling of Peyer’s Patch M Cells, Villous M-Like Cells, and Intestinal Epithelial Cells

Kazutaka Terahara, Masato Yoshida, Osamu Igarashi, +10

The Journal of Immunology

A novel M cell–specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses

Tomonori Nochi, Yoshikazu Yuki, Akiko Matsumura, +10

The Journal of Experimental Medicine

Nanogel-Based PspA Intranasal Vaccine Prevents Invasive Disease and Nasal Colonization by Streptococcus pneumoniae

Il Gyu Kong, Ayuko Sato, Yoshikazu Yuki, +13

Infection and Immunity

Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques

Yoshiko Fukuyama, Yoshikazu Yuki, Yuko Katakai, +15

Mucosal Immunology

Pspa-specific Serum IggImmunologyCd4 T Cell ResponsesImmunotherapyNanogel-based Pneumococcal Surface +16

Secretory IgA-mediated protection against<i>V. cholerae</i>and heat-labile enterotoxin-producing enterotoxigenic<i>Escherichia coli</i>by rice-based vaccine

Daisuke Tokuhara, Yoshikazu Yuki, Tomonori Nochi, +9

Proceedings of the National Academy of Sciences

Microbial PathogensImmunologyBacterial PathogensOral ImmunizationEnterotoxigenic Escherichia Coli +14

Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection

Daisuke Tokuhara, Beatriz Álvarez, Mio Mejima, +15

Journal of Clinical Investigation

Microbial PathogensViral DiagnosticsImmunologyViral PathogenesisImmunodominance +14

A Rice-Based Oral Cholera Vaccine Induces Macaque-Specific Systemic Neutralizing Antibodies but Does Not Influence Pre-Existing Intestinal Immunity

Tomonori Nochi, Yoshikazu Yuki, Yuko Katakai, +12

The Journal of Immunology

Induction of toxin‐specific neutralizing immunity by molecularly uniform rice‐based oral cholera toxin B subunit vaccine without plant‐associated sugar modification

Yoshikazu Yuki, Mio Mejima, Shiho Kurokawa, +18

Plant Biotechnology Journal